<?xml version="1.0" encoding="UTF-8"?> <!DOCTYPE book PUBLIC "-//NLM//DTD BITS Book Interchange DTD v2.3 20210610//EN" "BITS-book2.3.dtd"> <book xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" book-type="conference-proceedings" dtd-version="2.3" xml:lang="ru"> <front> <book-meta>  <book-id book-id-type="isbn">978-5-907965-64-5</book-id>   <book-id pub-id-type="doi">10.31483/a-10716</book-id>   <title-group>  <book-title xml:lang="ru">Фундаментальные и прикладные исследования по приоритетным направлениям биоэкологии и биотехнологии</book-title>   <trans-title-group xml:lang="en"> <trans-title>Fundamental and applied research for key propriety areas of bioecology and biotechnology</trans-title> </trans-title-group>  </title-group>  <description xml:lang="ru"> <p>В сборнике представлены статьи участников VIII Всероссийской научно-практической конференции «Фундаментальные и прикладные исследования по приоритетным направлениям биоэкологии и биотехнологии». В материалах сборника приведены результаты теоретических и прикладных изысканий представителей научного и образовательного сообщества в области биологии и медицины. Статьи представлены в авторской редакции.</p> </description>   <contrib-group>  <contrib contrib-type="editor" id="editor1">  <contrib-id contrib-id-type="role">chief_editor</contrib-id>    <name-alternatives>  <name name-style="eastern" xml:lang="ru"> <surname>Антонова</surname> <given-names>Елена Ивановна</given-names> </name>   <name name-style="western" xml:lang="en"> <surname>Antonova</surname> <given-names>Elena Ivanovna</given-names> </name>  </name-alternatives>  <contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3686-9686</contrib-id> <email xlink:type="simple">antonov_67@mail.ru</email> </contrib>  <contrib contrib-type="editor" id="editor2">    <name-alternatives>  <name name-style="eastern" xml:lang="ru"> <surname>Ленгесова</surname> <given-names>Наталья Анатольевна</given-names> </name>   <name name-style="western" xml:lang="en"> <surname>Lengesova</surname> <given-names>Natal&#039;ia Anatol&#039;evna</given-names> </name>  </name-alternatives>  <contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7512-6386</contrib-id> <email xlink:type="simple">lengesova@yandex.ru</email> </contrib>  <contrib contrib-type="editor" id="editor3">    <name-alternatives>  <name name-style="eastern" xml:lang="ru"> <surname>Фирсова</surname> <given-names>Наталья Викторовна</given-names> </name>   <name name-style="western" xml:lang="en"> <surname>Firsova</surname> <given-names>Natalia Viktorovna</given-names> </name>  </name-alternatives>  <contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9907-8857</contrib-id> <email xlink:type="simple">n-firsova@mail.ru</email> </contrib>  </contrib-group>   <contrib-group>  <contrib contrib-type="member-of-organizing-committee" id="orgcomm1">    <name-alternatives>  <name name-style="eastern" xml:lang="ru"> <surname>Антонова</surname> <given-names>Елена Ивановна</given-names> </name>   <name name-style="western" xml:lang="en"> <surname>Antonova</surname> <given-names>Elena Ivanovna</given-names> </name>  </name-alternatives>  <contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3686-9686</contrib-id> </contrib>  <contrib contrib-type="member-of-organizing-committee" id="orgcomm2">    <name-alternatives>  <name name-style="eastern" xml:lang="ru"> <surname>Антонова</surname> <given-names>Елена Ивановна</given-names> </name>   <name name-style="western" xml:lang="en"> <surname>Antonova</surname> <given-names>Elena Ivanovna</given-names> </name>  </name-alternatives>  <contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3686-9686</contrib-id> </contrib>  <contrib contrib-type="member-of-organizing-committee" id="orgcomm3">    <name-alternatives>  <name name-style="eastern" xml:lang="ru"> <surname>Ленгесова</surname> <given-names>Наталья Анатольевна</given-names> </name>   <name name-style="western" xml:lang="en"> <surname>Lengesova</surname> <given-names>Natal&#039;ia Anatol&#039;evna</given-names> </name>  </name-alternatives>  <contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7512-6386</contrib-id> </contrib>  <contrib contrib-type="member-of-organizing-committee" id="orgcomm4">    <name-alternatives>  <name name-style="eastern" xml:lang="ru"> <surname>Беззубенкова</surname> <given-names>Ольга Евгеньевна</given-names> </name>   <name name-style="western" xml:lang="en"> <surname>Bezzubenkova</surname> <given-names>Ol&#039;ga Evgen&#039;evna</given-names> </name>  </name-alternatives>  <contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3243-6381</contrib-id> </contrib>  <contrib contrib-type="member-of-organizing-committee" id="orgcomm5">    <name-alternatives>  <name name-style="eastern" xml:lang="ru"> <surname>Коняев</surname> <given-names>Игорь Сергеевич</given-names> </name>   <name name-style="western" xml:lang="en"> <surname>Koniaev</surname> <given-names>Igor&#039; Sergeevich</given-names> </name>  </name-alternatives>   </contrib>  <contrib contrib-type="member-of-organizing-committee" id="orgcomm6">    <name-alternatives>  <name name-style="eastern" xml:lang="ru"> <surname>Масленников</surname> <given-names>Андрей Викторович</given-names> </name>   <name name-style="western" xml:lang="en"> <surname>Maslennikov</surname> <given-names>Andrei Viktorovich</given-names> </name>  </name-alternatives>  <contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1421-7484</contrib-id> </contrib>  <contrib contrib-type="member-of-organizing-committee" id="orgcomm7">    <name-alternatives>  <name name-style="eastern" xml:lang="ru"> <surname>Куницына</surname> <given-names>Анастасия Владимировна</given-names> </name>   <name name-style="western" xml:lang="en"> <surname>Khambikova</surname> <given-names>Anastasiia Vladimirovna</given-names> </name>  </name-alternatives>   </contrib>  <contrib contrib-type="member-of-organizing-committee" id="orgcomm8">    <name-alternatives>  <name name-style="eastern" xml:lang="ru"> <surname>Фирсова</surname> <given-names>Наталья Викторовна</given-names> </name>   <name name-style="western" xml:lang="en"> <surname>Firsova</surname> <given-names>Natalia Viktorovna</given-names> </name>  </name-alternatives>  <contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9907-8857</contrib-id> </contrib>  </contrib-group>   <event>  <event-desc xml:lang="ru">Фундаментальные и прикладные исследования по приоритетным направлениям биоэкологии и биотехнологии</event-desc>   <event-desc xml:lang="en">Fundamental and applied research for key propriety areas of bioecology and biotechnology</event-desc>   <conf-date> <day>22</day> <month>05</month> <year>2025</year> </conf-date>    <conf-loc xml:lang="ru">Ульяновск</conf-loc>  </event>   <publisher> <publisher-name>ИД «Среда»</publisher-name> </publisher>    <pub-date date-type="collection" publication-format="electronic" iso-8601-date="1900"> <year>1900</year> </pub-date>    <permissions>  <copyright-statement xml:lang="en">© 2025 Daria V. Iakovleva, Aidar R. Zimnurov, Iuliia A. Anashkina, Natalia V. Firsova, Konstantin N. Firsov, Elena I. Antonova</copyright-statement>   <copyright-statement xml:lang="ru">© 2025 Яковлева Д. В., Зимнуров А. Р., Анашкина Ю. А., Фирсова Н. В., Фирсов К. Н., Антонова Е. И.</copyright-statement>   <copyright-year>2025</copyright-year>  <copyright-holder xml:lang="ru">Яковлева Д. В., Зимнуров А. Р., Анашкина Ю. А., Фирсова Н. В., Фирсов К. Н., Антонова Е. И.</copyright-holder>   <copyright-holder xml:lang="en">Daria V. Iakovleva, Aidar R. Zimnurov, Iuliia A. Anashkina, Natalia V. Firsova, Konstantin N. Firsov, Elena I. Antonova</copyright-holder>    <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/" xml:lang="en" xlink:type="simple"> <license-p>This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0)</license-p> </license>   <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/" xml:lang="ru" xlink:type="simple"> <license-p>Это произведение доступно по лицензии Creative Commons Attribution 4.0 International (CC BY 4.0)</license-p> </license>   </permissions>  </book-meta> <book-part book-part-type="conference-paper"> <book-part-meta>  <book-id pub-id-type="doi">10.31483/r-139064</book-id>   <book-id custom-type="publisher-id" pub-id-type="custom">139064</book-id> <title-group>  <chapter-title xml:lang="ru">FISH-технологии в области клинических и фундаментальных исследованиях (обзор литературы)</chapter-title>   <trans-title-group xml:lang="en"> <trans-title>FISH technologies in the field of clinical and basic research (literature review)</trans-title> </trans-title-group>  </title-group>  <contrib-group>   <contrib contrib-type="author" id="author1">   <name-alternatives>  <name name-style="eastern" xml:lang="ru"> <surname>Яковлева</surname> <given-names>Дарья Васильевна</given-names> </name>   <name name-style="western" xml:lang="en"> <surname>Iakovleva</surname> <given-names>Daria Vasilevna</given-names> </name>   </name-alternatives>  <email xlink:type="simple">kivi54321@mail.ru</email> <xref ref-type="aff" rid="aff1"/> </contrib>   <contrib contrib-type="author" id="author2">   <name-alternatives>  <name name-style="eastern" xml:lang="ru"> <surname>Зимнуров</surname> <given-names>Айдар Раилевич</given-names> </name>   <name name-style="western" xml:lang="en"> <surname>Zimnurov</surname> <given-names>Aidar Railevich</given-names> </name>   </name-alternatives>  <email xlink:type="simple">zimnurov75@gmail.com</email> <xref ref-type="aff" rid="aff1"/> </contrib>   <contrib contrib-type="author" id="author3">   <name-alternatives>  <name name-style="eastern" xml:lang="ru"> <surname>Анашкина</surname> <given-names>Юлия Анатольевна</given-names> </name>   <name name-style="western" xml:lang="en"> <surname>Anashkina</surname> <given-names>Iuliia Anatol&#039;evna</given-names> </name>   </name-alternatives>  <email xlink:type="simple">maela.loivissa@yandex.ru</email> <xref ref-type="aff" rid="aff2"/> </contrib>   <contrib contrib-type="author" id="author4"> <contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9907-8857</contrib-id>  <name-alternatives>  <name name-style="eastern" xml:lang="ru"> <surname>Фирсова</surname> <given-names>Наталья Викторовна</given-names> </name>   <name name-style="western" xml:lang="en"> <surname>Firsova</surname> <given-names>Natalia Viktorovna</given-names> </name>   </name-alternatives>  <email xlink:type="simple">n-firsova@mail.ru</email> <xref ref-type="aff" rid="aff1"/> </contrib>   <contrib contrib-type="author" id="author5">   <name-alternatives>  <name name-style="eastern" xml:lang="ru"> <surname>Фирсов</surname> <given-names>Константин Николаевич</given-names> </name>   <name name-style="western" xml:lang="en"> <surname>Firsov</surname> <given-names>Konstantin Nikolaevich</given-names> </name>   </name-alternatives>   <xref ref-type="aff" rid="aff2"/> </contrib>   <contrib contrib-type="author" id="author6"> <contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3686-9686</contrib-id>  <name-alternatives>  <name name-style="eastern" xml:lang="ru"> <surname>Антонова</surname> <given-names>Елена Ивановна</given-names> </name>   <name name-style="western" xml:lang="en"> <surname>Antonova</surname> <given-names>Elena Ivanovna</given-names> </name>   </name-alternatives>  <email xlink:type="simple">antonov_67@mail.ru</email> <xref ref-type="aff" rid="aff1"/> </contrib>    <aff-alternatives id="aff1">   <aff xml:lang="ru">  <institution>Научно-исследовательский центр фундаментальных и прикладных проблем биоэкологии и биотехнологии ФГБОУ ВО «Ульяновский государственный педагогический университет им. И.Н. Ульянова»</institution>   <country>Россия</country> </aff>    <aff xml:lang="en">  <institution>Nauchno-issledovatel&#039;skii tsentr fundamental&#039;nykh i prikladnykh problem bioekologii i biotekhnologii FGBOU VO &quot;Ul&#039;ianovskii gosudarstvennyi pedagogicheskii universitet im. I.N. Ul&#039;ianova&quot;</institution>   <country>Russia</country> </aff>   </aff-alternatives>  <aff-alternatives id="aff2">   <aff xml:lang="ru">  <institution-wrap> <institution-id institution-id-type="ror">00j0x9b96</institution-id> <institution>Ульяновский государственный педагогический университет им. И.Н. Ульянова</institution> </institution-wrap>   <country>Россия</country> </aff>    <aff xml:lang="en">  <institution-wrap> <institution-id institution-id-type="ror">00j0x9b96</institution-id> <institution>Ulyanovsk State Pedagogical University named after I. N. Ulyanov</institution> </institution-wrap>   <country>Russia</country> </aff>     </aff-alternatives>  </contrib-group>   <fpage>56</fpage> <lpage>68</lpage>   <abstract xml:lang="ru"> <p>статье рассматриваются методы технологии FISH (флуоресцентной in situ гибридизации), их модификации, применение в клинической диагностике и фундаментальных исследованиях.</p> </abstract>           <kwd-group xml:lang="ru">  <kwd>хромосома</kwd>  <kwd>FISH</kwd>  <kwd>молекулярная цитогенетика</kwd>  <kwd>ДНК-зонд</kwd>  <kwd>аберрации</kwd>  <kwd>флуорохром</kwd>  <kwd>генетическая диагностика</kwd>  <kwd>ген</kwd>  <kwd>гибридизация</kwd>  <kwd>ДНК-последовательность</kwd>  </kwd-group>        </book-part-meta> </book-part> </front>  <back> <ref-list> <title>References</title>  <ref id="ref1"> <label>1</label> <citation-alternatives>  <mixed-citation xml:lang="ru">Нугиc В.Ю. FISH-метод: способ цитогенетической ретроспективной оценки дозы (обзор) / В.Ю. Нугис // Саратовский научно-медицинский журнал. – 2016. – №12 (4). – С. 671–678. EDN YPYFKV</mixed-citation>    </citation-alternatives> <element-citation publication-type="other">  <person-group person-group-type="author">  <name> <surname>Нугиc</surname> <given-names>В. Ю.</given-names> </name>  </person-group>   <article-title>FISH-метод: способ цитогенетической ретроспективной оценки дозы (обзор)</article-title> <source>Саратовский научно-медицинский журнал</source> <year>2016</year>  <issue>12 (4)</issue> <fpage>671</fpage> <lpage>678</lpage>  <pub-id pub-id-type="custom" custom-type="edn">YPYFKV</pub-id>       </element-citation> </ref>  <ref id="ref2"> <label>2</label> <citation-alternatives>  <mixed-citation xml:lang="ru">Bishop R. Applications of fluorescence in situ hybridization (FISH) in detecting genetic aberrations of medical significance // Bioscience Horizons: The International Journal of Student Research. 2010. Vol. 3. №1. Pp. 85–95.</mixed-citation>    </citation-alternatives> <element-citation publication-type="other">  <person-group person-group-type="author">  <name> <surname>Bishop</surname> <given-names>R.</given-names> </name>  </person-group>   <article-title>Applications of fluorescence in situ hybridization (FISH) in detecting genetic aberrations of medical significance</article-title> <source>Bioscience Horizons: The International Journal of Student Research</source> <year>2010</year> <volume>3</volume> <issue>1</issue> <fpage>85</fpage> <lpage>95</lpage>         </element-citation> </ref>  <ref id="ref3"> <label>3</label> <citation-alternatives>  <mixed-citation xml:lang="ru">Boyd C., Boyle D. Molecular diagnosis on tissues and cells: how it affects training and will affect practice in the future // Cytopathology. 2012. №23 (5). – Pp. 286–294.</mixed-citation>    </citation-alternatives> <element-citation publication-type="other">  <person-group person-group-type="author">  <name> <surname>Boyd</surname> <given-names>C.</given-names> </name>  <name> <surname>Boyle</surname> <given-names>D.</given-names> </name>  </person-group>   <article-title>Molecular diagnosis on tissues and cells: how it affects training and will affect practice in the future</article-title> <source>Cytopathology</source> <year>2012</year>  <issue>23 (5)</issue> <fpage>286</fpage> <lpage>294</lpage>         </element-citation> </ref>  <ref id="ref4"> <label>4</label> <citation-alternatives>  <mixed-citation xml:lang="ru">Carter D. How fluorescence in situ hybridization (FISH) fits into cancer care The University of Texas MD Anderson Cancer Center // The University of Texas MD Anderson Cancer Center. 2021.</mixed-citation>    </citation-alternatives> <element-citation publication-type="other">  <person-group person-group-type="author">  <name> <surname>Carter</surname> <given-names>D.</given-names> </name>  </person-group>   <article-title>How fluorescence in situ hybridization (FISH) fits into cancer care</article-title>               </element-citation> </ref>  <ref id="ref5"> <label>5</label> <citation-alternatives>  <mixed-citation xml:lang="ru">Casaluce F., Sgambato A., Maione P. [et al.]. C. ALK inhibitors: a new targeted therapy in the treatment of advanced NSCLC // Target Oncol. 2013. №8 (1). Pp. 55–67. DOI 10.1007/s11523-012-0250-9. EDN UMBEYJ</mixed-citation>    </citation-alternatives> <element-citation publication-type="other">  <person-group person-group-type="author">  <name> <surname>Casaluce</surname> <given-names>F.</given-names> </name>  <name> <surname>Sgambato</surname> <given-names>A.</given-names> </name>  <name> <surname>Maione</surname> <given-names>P.</given-names> </name>  </person-group>   <article-title>ALK inhibitors: a new targeted therapy in the treatment of advanced NSCLC</article-title> <source>Target Oncol</source> <year>2013</year>  <issue>8 (1)</issue> <fpage>55</fpage> <lpage>67</lpage> <pub-id pub-id-type="doi">10.1007/s11523-012-0250-9</pub-id> <pub-id pub-id-type="custom" custom-type="edn">UMBEYJ</pub-id>       </element-citation> </ref>  <ref id="ref6"> <label>6</label> <citation-alternatives>  <mixed-citation xml:lang="ru">Casper R.M., Leonard K., Mpho M., Bono N. Recent Molecular Techniques in Cytogenetics. 2025.</mixed-citation>    </citation-alternatives> <element-citation publication-type="other">  <person-group person-group-type="author">  <name> <surname>Casper</surname> <given-names>R. M.</given-names> </name>  <name> <surname>Leonard</surname> <given-names>K.</given-names> </name>  <name> <surname>Mpho</surname> <given-names>M.</given-names> </name>  <name> <surname>Bono</surname> <given-names>N.</given-names> </name>  </person-group>   <article-title>Recent Molecular Techniques in Cytogenetics</article-title>               </element-citation> </ref>  <ref id="ref7"> <label>7</label> <citation-alternatives>  <mixed-citation xml:lang="ru">Chen J., Shi Q., Zhang J. [et al.]. Detection of mosaic chromosome 21 aneuploidy in vivo with CB-FISH method // Chinese journal of medical genetics. 2000. Vol. 17 (3). Pp. 196–199.</mixed-citation>    </citation-alternatives> <element-citation publication-type="other">  <person-group person-group-type="author">  <name> <surname>Chen</surname> <given-names>J.</given-names> </name>  <name> <surname>Shi</surname> <given-names>Q.</given-names> </name>  <name> <surname>Zhang</surname> <given-names>J.</given-names> </name>  </person-group>   <article-title>Detection of mosaic chromosome 21 aneuploidy in vivo with CB-FISH method</article-title> <source>Chinese journal of medical genetics</source> <year>2000</year> <volume>17 (3)</volume>  <fpage>196</fpage> <lpage>199</lpage>         </element-citation> </ref>  <ref id="ref8"> <label>8</label> <citation-alternatives>  <mixed-citation xml:lang="ru">Chudova I. Fluorescence in situ hybridization. In: Chromosomal alterations: methods, results and importance in human’s health. Berlin, Heidelberg, New York: Springer-Verlag. 2007. Pp. 285–299.</mixed-citation>    </citation-alternatives> <element-citation publication-type="other">  <person-group person-group-type="author">  <name> <surname>Chudova</surname> <given-names>I.</given-names> </name>  </person-group>   <article-title>Fluorescence in situ hybridization. In: Chromosomal alterations: methods, results and importance in human’s health</article-title>     <fpage>285</fpage> <lpage>299</lpage>         </element-citation> </ref>  <ref id="ref9"> <label>9</label> <citation-alternatives>  <mixed-citation xml:lang="ru">Cytogenetic dosimetry: applications in preparedness for and response to radiation emergencies // Vienna: IAEA. 2011. P. 229.</mixed-citation>    </citation-alternatives> <element-citation publication-type="other">   <article-title>Cytogenetic dosimetry: applications in preparedness for and response to radiation emergencies</article-title>               </element-citation> </ref>  <ref id="ref10"> <label>10</label> <citation-alternatives>  <mixed-citation xml:lang="ru">de Barros A.V., Sczepanski Th.S., Cabrero J., Artoni R.F. Fiber FISH reveals different patterns of highresolution physical mapping for repetitive DNA in fish. // Aquaculture. 2018. Vol. 322. Pp. 47–50.</mixed-citation>    </citation-alternatives> <element-citation publication-type="other">  <person-group person-group-type="author">  <name> <surname>Barros</surname> <given-names>A. V.</given-names> </name>  <name> <surname>Sczepanski</surname> <given-names>Th. S.</given-names> </name>  <name> <surname>Cabrero</surname> <given-names>J.</given-names> </name>  <name> <surname>Artoni</surname> <given-names>R. F.</given-names> </name>  </person-group>   <article-title>Fiber FISH reveals different patterns of highresolution physical mapping for repetitive DNA in fish</article-title> <source>Aquaculture</source> <year>2018</year> <volume>322</volume>  <fpage>47</fpage> <lpage>50</lpage>         </element-citation> </ref>  <ref id="ref11"> <label>11</label> <citation-alternatives>  <mixed-citation xml:lang="ru">Dhabe A., Islam R., Ramakrishnan K., Parihar M. Role of Cytogenetics and FISH in laboratory workup of B cell precursor acute lymphoblastic leukemia // Indian J Med Paediatr Oncol. 2023. №44 (05). Pp. 482–493. DOI 10.1055/s-0043-1766133. EDN VXODKF</mixed-citation>    </citation-alternatives> <element-citation publication-type="other">  <person-group person-group-type="author">  <name> <surname>Dhabe</surname> <given-names>A.</given-names> </name>  <name> <surname>Islam</surname> <given-names>R.</given-names> </name>  <name> <surname>Ramakrishnan</surname> <given-names>K.</given-names> </name>  <name> <surname>Parihar</surname> <given-names>M.</given-names> </name>  </person-group>   <article-title>Role of Cytogenetics and FISH in laboratory workup of B cell precursor acute lymphoblastic leukemia</article-title> <source>Indian J Med Paediatr Oncol</source> <year>2023</year>  <issue>44 (05)</issue> <fpage>482</fpage> <lpage>493</lpage> <pub-id pub-id-type="doi">10.1055/s-0043-1766133</pub-id> <pub-id pub-id-type="custom" custom-type="edn">VXODKF</pub-id>       </element-citation> </ref>  <ref id="ref12"> <label>12</label> <citation-alternatives>  <mixed-citation xml:lang="ru">Dietel M., Johrens K., Laffert M. [et al.]. Predictive molecular pathology and its role in targeted cancer therapy: a review focussing on clinical relevance // Cancer Gene Ther. 2013. №20 (4). Pp. 211–221.</mixed-citation>    </citation-alternatives> <element-citation publication-type="other">  <person-group person-group-type="author">  <name> <surname>Dietel</surname> <given-names>M.</given-names> </name>  <name> <surname>Johrens</surname> <given-names>K.</given-names> </name>  <name> <surname>Laffert</surname> <given-names>M.</given-names> </name>  </person-group>   <article-title>Predictive molecular pathology and its role in targeted cancer therapy: a review focussing on clinical relevance</article-title> <source>Cancer Gene Ther</source> <year>2013</year>  <issue>20 (4)</issue> <fpage>211</fpage> <lpage>221</lpage>         </element-citation> </ref>  <ref id="ref13"> <label>13</label> <citation-alternatives>  <mixed-citation xml:lang="ru">Eckel H., Kleinstein J., Wieacker P., Stumm M. Multi-locus (ML)-FISH is a reliable tool for nondisjunction studies in human oocytes // Cytogenet. Genome. 2003. №103. Pp. 47–53.</mixed-citation>    </citation-alternatives> <element-citation publication-type="other">  <person-group person-group-type="author">  <name> <surname>Eckel</surname> <given-names>H.</given-names> </name>  <name> <surname>Kleinstein</surname> <given-names>J.</given-names> </name>  <name> <surname>Wieacker</surname> <given-names>P.</given-names> </name>  <name> <surname>Stumm</surname> <given-names>M.</given-names> </name>  </person-group>   <article-title>Multi-locus (ML)-FISH is a reliable tool for nondisjunction studies in human oocytes</article-title> <source>Cytogenet. Genome</source> <year>2003</year>  <issue>103</issue> <fpage>47</fpage> <lpage>53</lpage>         </element-citation> </ref>  <ref id="ref14"> <label>14</label> <citation-alternatives>  <mixed-citation xml:lang="ru">Gandhi L., Janne P. Crizotinib for ALK-rearranged non-small cell lung cancer: a new targeted therapy for a new target // Clin Cancer Res. 2012. Vol. 18 (14). Pp. 3737–3742.</mixed-citation>    </citation-alternatives> <element-citation publication-type="other">  <person-group person-group-type="author">  <name> <surname>Gandhi</surname> <given-names>L.</given-names> </name>  <name> <surname>Janne</surname> <given-names>P.</given-names> </name>  </person-group>   <article-title>Crizotinib for ALK-rearranged non-small cell lung cancer: a new targeted therapy for a new target</article-title> <source>Clin Cancer Res</source> <year>2012</year> <volume>18 (14)</volume>  <fpage>3737</fpage> <lpage>3742</lpage>         </element-citation> </ref>  <ref id="ref15"> <label>15</label> <citation-alternatives>  <mixed-citation xml:lang="ru">Hu L., Ru K., Zhang L. [et al.]. Fluorescence in situ hybridization (FISH): an increasingly demanded tool for biomarker research and personalized medicine // Biomarker Research. 2014. Vol. 2. DOI 10.1186/2050-7771-2-3. EDN EEHUMZ</mixed-citation>    </citation-alternatives> <element-citation publication-type="other">  <person-group person-group-type="author">  <name> <surname>Hu</surname> <given-names>L.</given-names> </name>  <name> <surname>Ru</surname> <given-names>K.</given-names> </name>  <name> <surname>Zhang</surname> <given-names>L.</given-names> </name>  </person-group>   <article-title>Fluorescence in situ hybridization (FISH): an increasingly demanded tool for biomarker research and personalized medicine</article-title> <source>Biomarker Research</source> <year>2014</year> <volume>2</volume>    <pub-id pub-id-type="doi">10.1186/2050-7771-2-3</pub-id> <pub-id pub-id-type="custom" custom-type="edn">EEHUMZ</pub-id>       </element-citation> </ref>  <ref id="ref16"> <label>16</label> <citation-alternatives>  <mixed-citation xml:lang="ru">Jiang H., Xue Y., Wang Q. [et al.]. The utility of fluorescence in situ hybridization analysis in diagnosing myelodysplastic syndromes is limited to cases with karyotype failure // Leuk Res. 2012. №36 (4). Pp. 448–452.</mixed-citation>    </citation-alternatives> <element-citation publication-type="other">  <person-group person-group-type="author">  <name> <surname>Jiang</surname> <given-names>H.</given-names> </name>  <name> <surname>Xue</surname> <given-names>Y.</given-names> </name>  <name> <surname>Wang</surname> <given-names>Q.</given-names> </name>  </person-group>   <article-title>The utility of fluorescence in situ hybridization analysis in diagnosing myelodysplastic syndromes is limited to cases with karyotype failure</article-title> <source>Leuk Res</source> <year>2012</year>  <issue>36 (4)</issue> <fpage>448</fpage> <lpage>452</lpage>         </element-citation> </ref>  <ref id="ref17"> <label>17</label> <citation-alternatives>  <mixed-citation xml:lang="ru">Khalaf S.D., Alhamadany A.Y., Kader M.A. Fluorescence in situ hybridization (FISH): types and application: a review // NTU Journal of Pure Sceinces. 2023. №2 (2). Pp. 37–53.</mixed-citation>    </citation-alternatives> <element-citation publication-type="other">  <person-group person-group-type="author">  <name> <surname>Khalaf</surname> <given-names>S. D.</given-names> </name>  <name> <surname>Alhamadany</surname> <given-names>A. Y.</given-names> </name>  <name> <surname>Kader</surname> <given-names>M. A.</given-names> </name>  </person-group>   <article-title>Fluorescence in situ hybridization (FISH): types and application: a review</article-title> <source>NTU Journal of Pure Sceinces</source> <year>2023</year>  <issue>2 (2)</issue> <fpage>37</fpage> <lpage>53</lpage>         </element-citation> </ref>  <ref id="ref18"> <label>18</label> <citation-alternatives>  <mixed-citation xml:lang="ru">Kim H., Lim S., Kim H. [et al.]. The frequency and impact of ROS1 rearrangement on clinical outcomes in never smokers with lung adenocarcinoma // Ann Oncol. 2013. №24 (9). Pp. 2364–2370.</mixed-citation>    </citation-alternatives> <element-citation publication-type="other">  <person-group person-group-type="author">  <name> <surname>Kim</surname> <given-names>H.</given-names> </name>  <name> <surname>Lim</surname> <given-names>S.</given-names> </name>  </person-group>   <article-title>The frequency and impact of ROS1 rearrangement on clinical outcomes in never smokers with lung adenocarcinoma</article-title> <source>Ann Oncol</source> <year>2013</year>  <issue>24 (9)</issue> <fpage>2364</fpage> <lpage>2370</lpage>         </element-citation> </ref>  <ref id="ref19"> <label>19</label> <citation-alternatives>  <mixed-citation xml:lang="ru">Landau D., Wu C. Chronic lymphocytic leukemia: molecular heterogeneity revealed by high-throughput genomics // Genome Med. 2013. №5 (5):47.</mixed-citation>    </citation-alternatives> <element-citation publication-type="other">  <person-group person-group-type="author">  <name> <surname>Landau</surname> <given-names>D.</given-names> </name>  <name> <surname>Wu</surname> <given-names>C.</given-names> </name>  </person-group>   <article-title>Chronic lymphocytic leukemia: molecular heterogeneity revealed by high-throughput genomics</article-title> <source>Genome Med</source> <year>2013</year>  <issue>5 (5)</issue>           </element-citation> </ref>  <ref id="ref20"> <label>20</label> <citation-alternatives>  <mixed-citation xml:lang="ru">Pathmanathan N., Bilous A. HER2 testing in breast cancer: an overview of current techniques and recent developments // Pathology. 2012. №44 (7). Pp. 587–595.</mixed-citation>    </citation-alternatives> <element-citation publication-type="other">  <person-group person-group-type="author">  <name> <surname>Pathmanathan</surname> <given-names>N.</given-names> </name>  <name> <surname>Bilous</surname> <given-names>A.</given-names> </name>  </person-group>   <article-title>HER2 testing in breast cancer: an overview of current techniques and recent developments</article-title> <source>Pathology</source> <year>2012</year>  <issue>44 (7)</issue> <fpage>587</fpage> <lpage>595</lpage>         </element-citation> </ref>  <ref id="ref21"> <label>21</label> <citation-alternatives>  <mixed-citation xml:lang="ru">Rubtsov N. Hybridization of nucleic acids in situ in the analysis of chromosomal abnormalities. In: Moleculargenetic methods in diagnostics of hereditary diseases and cancer. Introduction to molecular diagnostics // Moscow: Meditsina. – 2011. Vol. 2. Pp. 100–136.</mixed-citation>    </citation-alternatives> <element-citation publication-type="other">  <person-group person-group-type="author">  <name> <surname>Rubtsov</surname> <given-names>N.</given-names> </name>  </person-group>   <article-title>Hybridization of nucleic acids in situ in the analysis of chromosomal abnormalities</article-title> <source>Moscow: Meditsina</source> <year>2011</year> <volume>2</volume>  <fpage>100</fpage> <lpage>136</lpage>         </element-citation> </ref>  <ref id="ref22"> <label>22</label> <citation-alternatives>  <mixed-citation xml:lang="ru">Savage J., Simpson P. On the scoring of FISH- «painting» chromosome-type exchange aberrations // Mutat Res. 1994. №307 (1). Pp. 345–353.</mixed-citation>    </citation-alternatives> <element-citation publication-type="other">  <person-group person-group-type="author">  <name> <surname>Savage</surname> <given-names>J.</given-names> </name>  <name> <surname>Simpson</surname> <given-names>P.</given-names> </name>  </person-group>   <article-title>On the scoring of FISH- «painting» chromosome-type exchange aberrations</article-title> <source>Mutat Res</source> <year>1994</year>  <issue>307 (1)</issue> <fpage>345</fpage> <lpage>353</lpage>         </element-citation> </ref>  <ref id="ref23"> <label>23</label> <citation-alternatives>  <mixed-citation xml:lang="ru">Shakoori AR. Fluorescence In Situ Hybridization (FISH) and Its Applications // Chromosome Structure and Aberrations. 2017. №10. Pp. 343–367.</mixed-citation>    </citation-alternatives> <element-citation publication-type="other">   <article-title>Shakoori AR. Fluorescence In Situ Hybridization (FISH) and Its Applications</article-title> <source>Chromosome Structure and Aberrations</source> <year>2017</year>  <issue>10</issue> <fpage>343</fpage> <lpage>367</lpage>         </element-citation> </ref>  <ref id="ref24"> <label>24</label> <citation-alternatives>  <mixed-citation xml:lang="ru">Song J., Mooi WJ., Petronic-Rosic V. [et al.]. Nevus versus melanoma: to FISH, or not to FISH // Adv Anat Pathol. 2011. №18. Pp. 229–234.</mixed-citation>    </citation-alternatives> <element-citation publication-type="other">  <person-group person-group-type="author">  <name> <surname>Song</surname> <given-names>J.</given-names> </name>  <name> <surname>Petronic-Rosic</surname> <given-names>V.</given-names> </name>  </person-group>   <article-title>Nevus versus melanoma: to FISH, or not to FISH</article-title> <source>Adv Anat Pathol</source> <year>2011</year>  <issue>18</issue> <fpage>229</fpage> <lpage>234</lpage>         </element-citation> </ref>  <ref id="ref25"> <label>25</label> <citation-alternatives>  <mixed-citation xml:lang="ru">Stanley J., Hui H., Erber W. [et al.]. Analysis of human chromosomes by imaging flow cytometry. Cytometry Part B // Clinical Cytometry. 2021. №100 (5). Pp. 541–553.</mixed-citation>    </citation-alternatives> <element-citation publication-type="other">  <person-group person-group-type="author">  <name> <surname>Stanley</surname> <given-names>J.</given-names> </name>  <name> <surname>Hui</surname> <given-names>H.</given-names> </name>  <name> <surname>Erber</surname> <given-names>W.</given-names> </name>  </person-group>   <article-title>Analysis of human chromosomes by imaging flow cytometry. Cytometry Part B</article-title> <source>Clinical Cytometry</source> <year>2021</year>  <issue>100 (5)</issue> <fpage>541</fpage> <lpage>553</lpage>         </element-citation> </ref>  <ref id="ref26"> <label>26</label> <citation-alternatives>  <mixed-citation xml:lang="ru">Tanke H.J., Wiegant J., van Gijlswijk R. [et al.]. New strategy for multi-colour fluorescence in situ hybridisation: COBRA: combined binary ratio labelling // Eur. J. Hum. Genet. 1999. №7. Pp. 2–11.</mixed-citation>    </citation-alternatives> <element-citation publication-type="other">  <person-group person-group-type="author">  <name> <surname>Tanke</surname> <given-names>H. J.</given-names> </name>  <name> <surname>Wiegant</surname> <given-names>J.</given-names> </name>  <name> <surname>Gijlswijk</surname> <given-names>R.</given-names> </name>  </person-group>   <article-title>New strategy for multi-colour fluorescence in situ hybridisation: COBRA: combined binary ratio labelling</article-title> <source>Eur. J. Hum. Genet</source> <year>1999</year>  <issue>7</issue> <fpage>2</fpage> <lpage>11</lpage>         </element-citation> </ref>  <ref id="ref27"> <label>27</label> <citation-alternatives>  <mixed-citation xml:lang="ru">Tubbs R., Pettay J., Roche P. [et al.]. Concomitant oncoprotein detection with fluorescence in situ hybridization (CODFISH): a fluorescence-based assay enabling simultaneous visualization of gene amplification and encoded protein expression // J. Mol. Diagn. 2000. №2. Pp. 78–83.</mixed-citation>    </citation-alternatives> <element-citation publication-type="other">  <person-group person-group-type="author">  <name> <surname>Tubbs</surname> <given-names>R.</given-names> </name>  </person-group>   <article-title>Concomitant oncoprotein detection with fluorescence in situ hybridization (CODFISH): a fluorescence-based assay enabling simultaneous visualization of gene amplification and encoded protein expression</article-title> <source>J. Mol. Diagn</source> <year>2000</year>  <issue>2</issue> <fpage>78</fpage> <lpage>83</lpage>         </element-citation> </ref>  <ref id="ref28"> <label>28</label> <citation-alternatives>  <mixed-citation xml:lang="ru">Tucker J., Morgan W., Awa A. [et al.]. A proposed system for scoring structural aberrations detected by chromosome painting // Cytogenet Cell Genet. 1995. №68 (3–4). Pp. 211–221.</mixed-citation>    </citation-alternatives> <element-citation publication-type="other">  <person-group person-group-type="author">  <name> <surname>Tucker</surname> <given-names>J.</given-names> </name>  <name> <surname>Morgan</surname> <given-names>W.</given-names> </name>  <name> <surname>Awa</surname> <given-names>A.</given-names> </name>  </person-group>   <article-title>[A proposed system for scoring structural aberrations detected by chromosome painting</article-title> <source>Cytogenet Cell Genet</source> <year>1995</year>  <issue>68 (3–4)</issue> <fpage>211</fpage> <lpage>221</lpage>         </element-citation> </ref>  <ref id="ref29"> <label>29</label> <citation-alternatives>  <mixed-citation xml:lang="ru">Volpi E.V., Bridger J.M. FISH glossary: an overview of the fluorescence in situ hybridization technique. 2018.</mixed-citation>    </citation-alternatives> <element-citation publication-type="other">  <person-group person-group-type="author">  <name> <surname>Volpi</surname> <given-names>E. V.</given-names> </name>  <name> <surname>Bridger</surname> <given-names>J. M.</given-names> </name>  </person-group>   <article-title>FISH glossary: an overview of the fluorescence in situ hybridization technique</article-title>               </element-citation> </ref>  <ref id="ref30"> <label>30</label> <citation-alternatives>  <mixed-citation xml:lang="ru">Volpi E.V., Bridger J.M. FISH glossary: an overview of the fluorescence in situ hybridization technique // BioTechniques. 2008. №45. Pp. 385–409. DOI 10.2144/000112811. EDN MMGAIL</mixed-citation>    </citation-alternatives> <element-citation publication-type="other">  <person-group person-group-type="author">  <name> <surname>Volpi</surname> <given-names>E. V.</given-names> </name>  <name> <surname>Bridger</surname> <given-names>J. M.</given-names> </name>  </person-group>   <article-title>FISH glossary: an overview of the fluorescence in situ hybridization technique</article-title> <source>BioTechniques</source> <year>2008</year>  <issue>45</issue> <fpage>385</fpage> <lpage>409</lpage> <pub-id pub-id-type="doi">10.2144/000112811</pub-id> <pub-id pub-id-type="custom" custom-type="edn">MMGAIL</pub-id>       </element-citation> </ref>  <ref id="ref31"> <label>31</label> <citation-alternatives>  <mixed-citation xml:lang="ru">Wertheim G., Hexner E., Bagg A. Molecular-based classification of acute myeloid leukemia and its role in directing rational therapy: personalized medicine for profoundly promiscuous proliferations // Mol Diagn Ther. 2012. №16 (6). Pp. 357–369.</mixed-citation>    </citation-alternatives> <element-citation publication-type="other">  <person-group person-group-type="author">  <name> <surname>Wertheim</surname> <given-names>G.</given-names> </name>  <name> <surname>Hexner</surname> <given-names>E.</given-names> </name>  <name> <surname>Bagg</surname> <given-names>A.</given-names> </name>  </person-group>   <article-title>Molecular-based classification of acute myeloid leukemia and its role in directing rational therapy: personalized medicine for profoundly promiscuous proliferations</article-title> <source>Mol Diagn Ther</source> <year>2012</year>  <issue>16 (6)</issue> <fpage>357</fpage> <lpage>369</lpage>         </element-citation> </ref>  <ref id="ref32"> <label>32</label> <citation-alternatives>  <mixed-citation xml:lang="ru">Wolff D., Bagg A., Cooley L. [et al.]. Guidance for Fluorescence in situ Hybridization Testing in Hematologic Disorders // SPECIAL ARTICLE. 2007. Vol. 9. №2. Pp. 134–143.</mixed-citation>    </citation-alternatives> <element-citation publication-type="other">  <person-group person-group-type="author">  <name> <surname>Wolff</surname> <given-names>D.</given-names> </name>  <name> <surname>Bagg</surname> <given-names>A.</given-names> </name>  <name> <surname>Cooley</surname> <given-names>L.</given-names> </name>  </person-group>   <article-title>Guidance for Fluorescence in situ Hybridization Testing in Hematologic Disorders</article-title> <source>SPECIAL ARTICLE</source> <year>2007</year> <volume>9</volume> <issue>2</issue> <fpage>134</fpage> <lpage>143</lpage>         </element-citation> </ref>  </ref-list> </back>  </book>