Fundamental and applied research for key propriety areas of bioecology and biotechnology
- Authors:
- Iuliia A. Kudrova, Sofia V. Erzukova
- Work direction:
- Биохимия. Биомедицинские технологии
- Abstract:
- Systemic sclerosis (SSc) is a rare connective tissue disorder characterized by vasculopathy, abnormal immune system activation with autoantibody production, and fibrosis development. This article reviews current therapeutic approaches for SSc, including the use of methotrexate, tofacitinib, and ziritaxestat. It discusses the role of interleukin-17 (IL-17) in disease pathogenesis and the potential of brodalumab, an IL-17 inhibitor, in reducing the modified Rodnan skin score (mRSS) and skin thickness. The study aims to systematically analyze the pathogenesis, clinical manifestations, and dermatological changes associated with SSc. Conclusions: Investigating the role of autoantibodies and cytokines in the pathogenesis of systemic sclerosis reveals the molecular mechanisms underlying fibrosis and chronic inflammation. Understanding these processes enables the development of therapeutic strategies, including the suppression of pro-inflammatory cytokines and blockade of autoantibodies.
- Keywords:
- systemic sclerosis, biomarker, topoisomerase, Rodnan skin score, autoantibodies
Fundamental and applied research for key propriety areas of bioecology and biotechnology