Fundamental and applied research for key propriety areas of bioecology and biotechnology
- Authors:
- Shaimaa Hamza, Ekaterina E. Garanina, Ekaterina V. Martynova, Maria I. Markelova, Jurij N. Davidyuk, Venera G. Shakirova, Svetlana F. Khaibullina
- Work direction:
- Биохимия и токсикология (биохимические, иммунологические, токсикологические исследования)
- Abstract:
- Identifying immunogenic targets of SARS-CoV-2 is essential to develop novel treatments. The authors of the article studied humoral immune responses to spike (S) and nucleocapsid (N) SARS-CoV-2 proteins in serum from convalescent COVID-19 patients from Tatarstan, Russia. Multiple SARS-CoV-2 peptides were identified as reacting with convalescent COVID-19 serum. In addition, age and gender associated differences in the reactivity to S and N protein peptides were identified. Changing pattern of immunogenic peptide reactivity in COVID-19 serum based on age and gender was demonstrated. These data highlight how humoral immune responses to some of these peptides could contribute to SARS-CoV-2 pathogenesis.
- Keywords:
- Covid-19, SARS-CoV-2, spike protein, peptides, antibody humoral immune response