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List of publications on a keyword: «метаболиты»

  • Maldi-tof as a tool for noninvasive cancer marker screening in the context of personalized medicine development

    Conference Paper
    Fundamental and applied research for key propriety areas of bioecology and biotechnology
    Authors:
    Elena I. Antonova, Anastasiia V. Khambikova, Atabeg B. Achilov, Stepan A. Shishin
    Work direction:
    Молекулярная биология
    Abstract:
    В статье ретроспективно за последние 26 лет рассматривается роль масс-спектрометрии (МS) в изучении онкогенеза и поиска диагностических и прогностических биомаркеров злокачественно трансформированных клеток. Несмотря на существующие ограничения, будущее МS в онкологии остается многообещающим благодаря значительным достижениям в области интеграции данных на основе машинного обучения, портативных устройств для отбора проб и клинических исследований, которые продвигают метаомиксные технологии в направление прецизионной терапии.
    Keywords:
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  • Seasonal changes in serum metabolite and cytokine levels in Multiple Sclerosis

    Conference Paper
    Fundamental and applied research for key propriety areas of bioecology and biotechnology
    Authors:
    Vera R. Lezhniova, Ekaterina V. Martynova, Timur I. Khaibullin, Ilnur I. Salafutdinov, Mariia I. Markelova, Aleksandr V. Laikov, Leonid V. Lopukhov, Svetlana F. Khaibullina
    Work direction:
    Биохимия и токсикология (биохимические, иммунологические, токсикологические исследования)
    Abstract:
    Multiple sclerosis (MS) is a chronic debilitating disease of unknown etiology. The disease has a seasonal exacerbation of clinical symptoms, which are frequently described in spring and summer. However, the mechanisms of such seasonal exacerbations remain unknown. In this study, we used targeted metabolomics analysis of serum samples using LC-MC/MC to determine seasonal changes in metabolites. We have found changes in multiple metabolites which differed depending on season. The ceramides, belonging to the sphingolipid pathway, were found activated in spring-summer (SS) and fall-winter (FW) MS, suggesting their central role in disease pathogenesis. Our identification of ceramide activation suggests a mechanism of neuron damage in MS which could be further investigated as therapeutic targets.
    Keywords:
    multiple sclerosis, metabolites, season exacerbation, pathogenesis
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