Fundamental and applied research for key propriety areas of bioecology and biotechnology
- Author:
- Abobakr M. Khussein
- Work direction:
- Клеточная биология, цитология, гистология, анатомия и физиология
- Abstract:
- The ability of cells to sense and respond to mechanical signals is vital in development functioning of healthy tissue. Many diseases are correlated to either changing mechanical properties of the tissue, or changes in the ability of cells to sense mechanical signals. This ssensing happens in part, at integrin-associated complexes (IACs) that form sites of attachment between the cell and the extracellular matrix (ECM). In this review, we will discuss the complex mechanical signals of the ECM and it's components: how cells sense mechanical stimuli, how mechanical signals are transmitted intracellularly, and what effects those signals have on cell function.
Since this is such a voluminous and complex topic, we have focused here on the generalities, rather than details of how a specific cell type responds to mechanical stimulation.
- Keywords:
- ECM, mechanotrasduction, Extracellular Matrix, Mechanical Stimuli
Fundamental and applied research for key propriety areas of bioecology and biotechnology