Otsenka mutatsionnogo statusa genov BRAF, NRAS i CDKN2A v dobrokachestvennykh obrazovaniiakh kozhi

Proceeding
DOI: 10.31483/r-106992
Open Access
All-Russian scientific conference with International Participation «Fundamental and applied research for key propriety areas of bioecology and biotechnology»
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All-Russian scientific conference with International Participation «Fundamental and applied research for key propriety areas of bioecology and biotechnology»
Authors:
Anastasiia V. Khambikova 1 , Anastasiia K. Koroleva 1 , Atabeg B. Achilov 1 , Elena I. Antonova 1
Work direction:
Молекулярная биология, генетика, микробиология
Pages:
66-73
Received: 26 May 2023

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798
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РИНЦ
1 Nauchno-issledovatel'skii tsentr fundamental'nykh i prikladnykh problem bioekologii i biotekhnologii FGBOU VO "Ul'ianovskii gosudarstvennyi pedagogicheskii universitet im. I.N. Ul'ianova"
For citation:
Khambikova A. V., Koroleva A. K., Achilov A. B., & Antonova E. I. (2023). Otsenka mutatsionnogo statusa genov BRAF, NRAS i CDKN2A v dobrokachestvennykh obrazovaniiakh kozhi. Fundamental and applied research for key propriety areas of bioecology and biotechnology, 66-73. Чебоксары: PH "Sreda". https://doi.org/10.31483/r-106992

Abstract

Невусы относят к доброкачественным меланоцитарным новообразованиям с неопределённым биологическим потенциалом. Между генами, ассоциированными с невусом и меланомой, а также между фенотипическими и клеточными особенностями невусов и меланомы проявляются выраженные корреляции. В связи с этим для эффективного мониторинга и ранней диагностики меланомы необходим одномоментный мультиплексный скрининг по всем основным драйверным мутациям. В статье отражены результаты молекулярно-генетических исследований мутаций генов BRAF, NRAS и CDKN2A пациентов с гистологическим заключением внутридермальный невус кожи.

References

  1. 1. Соколикова В.Б. Отличительные морфологические и молекулярно-генетические особенности меланомы кожи и диспластических невусов / В.Б. Соколикова, Ю.В. Можинская, Е.М. Непомнящая [и др.] // Молодой ученый. – 2016. – №15.2 (119.2). – С. 5–37.
  2. 2. Bastian B.C. The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia // Annual review of the Pathology. – 2014. – V. 9:239 – Р. 71.
  3. 3. Clark W.H. A study of tumor progression: the precursor lesions of superficial spreading and nodular melanoma / W.H. Clark, D.E. Elder, D. Guerry, M.N. Epstein, M.H Greene, M. Van Horn // Human Pathology. – 1984. – V. 15 (12). – P. 1147–1165.
  4. 4. Damsky W.E. Melanocytic nevi and melanoma: unraveling a complex relationship / WE Damsky, M Bosenberg // Oncogene. – 2017. – 36 (42). – P. 5771–16. – DOI 10.1038/onc.2017.189. – EDN YKCYLL
  5. 5. Gray-Schopfer V.C. Cellular senescence in naevi and immortalisation in melanoma: a role for p16? / V.C. Gray-Schopfer, H. Chong, J. Chow, T. Moss, Z.A. Abdel-Malek, R. Marais, D. Wynford-Thomas, D.C. Bennett [et al.] // British journal of cancer. – 2006. – 95 (4). – P. 496–505. – DOI 10.1038/sj.bjc.6603283. – EDN KYNMOF
  6. 6. Haenssle H.A. Association of patient risk factors and frequency of nevus-associated cutaneous melanomas / H.A. Haenssle, A. Mograby, A. Ngassa [et al.] // JAMA Dermatology. – 2016. – vol. 152, no. 3, pp. 291–298.
  7. 7. Kelleher F.C. Targeting NRAS in melanoma / F.C. Kelleher, G.A. McArthur // Cancer Journal. – 2012. – 18 (2). – Р. 132–6.
  8. 8. Mackiewicz-Wysocka М. Oncogenic BRAF mutations and p16 expression in melanocytic nevi and melanoma in the Polish population / М. Mackiewicz-Wysocka, Małgorzata [et al.] // Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. – 2017. – V. 34 (5) – P. 490–498.
  9. 9. Mohammadpour A. Melanoma: where we are and where we go / A. Mohammadpour, M. Derakhshan, H. Darabi [et al.] // Journal of Cellular Physiology. – 2019. – V. 234 (4). – P. 3307–3320. – DOI 10.1002/jcp.27286. – EDN BRXCCX
  10. 10. Malladi N.S.N. A descriptive observational study on clinical and dermoscopic features of benign melanocytic neoplasms / NSN Malladi, SB Chikhalkar [et al.] // Indian J Dermatol Venereol Leprol. – 2020. – 86 (3). – Р. 251–261.
  11. 11. Pratama A.Y. Description and Histopathology Type of Pigmentosus Nevus in Dustira Hospital and Cibabat Hospital Cimahi / A.Y. Pratama // Conference: 12th Annual Scientific Meeting, Medical Faculty, Universitas Jenderal Achmad Yani, International Symposium on «Emergency Preparedness and Dis-aster Response during COVID 19 Pandemic». – 2021. – vol. 37. – Р. 193–196.
  12. 12. Schadendorf D. Melanoma / D. Schadendorf, A.C.J. van Akkooi, C. Berking [et al.] // The Lancet. – 2018. – vol. 392, no. 10151. – pp. 971–984. – DOI 10.1016/S0140-6736(18)31559-9. – EDN YKDORF
  13. 13. Shain A.H. The genetic evolution of melanoma from precursor lesions / A.H. Shain, I. Yeh, I. Kovalyshyn [et al.] // The New England Journal of Medicine. – 2015. – vol. 373, no. 20. – pp. 1926–1936.
  14. 14. Shain A.H. From melanocytes to melanomas / A.H. Shain, B.C. Bastian // Nature reviews Cancer. – 2016. – 16. – Р. 345–58.
  15. 15. Shitara D. Mutational status of naevus-associated melanomas / D. Shitara, G. Tell-Marti, C. Badenas [et al.] // Br. J. Dermatol. – 2015. – 173 (3). – Р. 671–680.
  16. 16. Shitara D. Nevus-associated melanomas: clinicopathologic features / D Shitara, MM Nascimento, S Puig [et al.] //Am J Clin Pathol. – 2014. – 142. – Р. 485–491.
  17. 17. Siegel R.L. Cancer statistics / R.L. Siegel, K.D. Miller, A. Jemal // Cancer Journal for Clinicians – 2020. – vol. 70, no. 1, pp. 7–30.
  18. 18. Tan J.M. The BRAF and NRAS mutation prevalence in dermoscopic subtypes of acquired naevi reveals constitutive mitogen-activated protein kinase pathway activation / J.M. Tan, L.N. Tom, K. Jagirdar [et al.] // British Journal of Dermatology. – 2018. – 178. – Р. 191–7.
  19. 19. Wei Han. Identification, Validation, and Functional Annotations of Genome-Wide Profile Variation between Melanocytic Nevus and Malignant Melanoma / Wei Han, W.-H. Xu, J.-X. Wang et al. // BioMed Research International. – 2020. – 1840415.
  20. 20. Whiteman D.C. Melanocytic nevi, solar keratoses, and divergent path-ways to cutaneous melanoma / D.C. Whiteman [et al.] // Journal of the National Cancer Institute. – 2003. – 95. – Р. 806–812. – EDN ISMFFB
  21. 21. Yeh I. Bastian Clonal BRAF mutations in melanocytic nevi and initiating role of BRAF in melanocytic neoplasia / I. Yeh, B.C. von Deimling // Journal of the National Cancer Institute. – 2013. – 105. – Р. 917–919.

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