MECHANOTRANSDAUCTION: HOW CELLS SENSE AND REACT TO MECHANICAL STIMULATION
Annotation
the ability of cells to sense and respond to mechanical signals is vital in development functioning of healthy tissue. Many diseases are correlated to either changing mechanical properties of the tissue, or changes in the ability of cells to sense mechanical signals. This ssensing happens in part, at integrin-associated complexes (IACs) that form sites of attachment between the cell and the extracellular matrix (ECM). In this review, we will discuss the complex mechanical signals of the ECM and it's components: how cells sense mechanical stimuli, how mechanical signals are transmitted intracel...
more