Iuliia A. Kudrova

Systemic sclerosis (SSc) is a rare connective tissue disorder characterized by vasculopathy, abnormal immune system activation with autoantibody production, and fibrosis development. This article reviews current therapeutic approaches for SSc, including the use of methotrexate, tofacitinib, and ziritaxestat. It discusses the role of interleukin-17 (IL-17) in disease pathogenesis and the potential of brodalumab, an IL-17 inhibitor, in reducing the modified Rodnan skin score (mRSS) and skin thickness. The study aims to systematically analyze the pathogenesis, clinical manifestations, and dermato...